Northern Neuron - Researchers and Profiles
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Northern Neuron - Researchers and Profiles

Northern Neuron - Available in French and EnglishThe Northern Neuron profiles 11 Canadian researchers funded by the ALS Society of Canada and also features articles on the new horizons in ALS research in Canada and beyond.   The publication is available in both French and English

The Northern Neuron highlights research funded by the ALS Society, to inform readers of the promising directions in neuromuscular research toward treatments and a cure for ALS.

This publication is the property of the ALS Society of Canada and no part may be reproduced without its prior permission. Opinions expressed are not necessarily those of the ALS Society of Canada.

Feel free to pass it along or request more copies to distribute to friends and family members.  The publication is available in a hard copy print out, please contact the ALS Society of Canada if you require a hard copy.


Researcher News - The latest ALS researcher articles.
1.  ALS Society of Canada provides critical funding for new ALS scientists

The ALS Society of Canada is thrilled to announce the creation of the Ronald Peter Griggs Memorial Postdoctoral Fellowship in ALS Research. The Griggs Fellowship will be awarded to three post-doctora ◊

"ALS Society of Canada provides critical funding for new ALS scientists"
2.  ALS Society of Canada Funds Neuromuscular Disease Research in Partnership

TORONTO, July 9, 2009- The ALS Society of Canada is pleased to announce the four recipients of the 2009 Neuromuscular Research Partnership (NRP) grants. Recipients will receive funding for their proje ◊

"ALS Society of Canada Funds Neuromuscular Disease Research in Partnership"
3.  Denise A. Figlewicz, PhD - Vice President Research

Denise Figlewicz, PhD, was promoted to Vice President Research at the ALS Society of Canada on May 11, 2009. ◊

"Denise A. Figlewicz, PhD - Vice President Research"
4.  First Bernice Ramsay Discovery Grants Awarded

The ALS Society of Canada has awarded the 2008 Bernice Ramsay Discovery Grants in ALS Research to Avi Chakrabartty, PhD, and Alex Parker, PhD. Their projects are titled “Composition of ALS pathologica ◊

"First Bernice Ramsay Discovery Grants Awarded"
5.  Fellowship continues to keep Tim E. Noël's spirit alive

Tim E. Noël’s philosophy of life was simple: “Today is a gift. That's why they call it the present. And you should never let the thieves of yesterday or tomorrow rob you of that gift.” Diagnosed with ◊

"Fellowship continues to keep Tim E. Noël's spirit alive"
6.  Milton Safenowitz Fellowship awarded to University of Toronto researcher

Teresa Sanelli, PhD, is the 2008 recipient of The ALS Association’s Milton Safenowitz Post-doctoral Fellowship for ALS Research, the only fellowship of its kind in the United States. A researcher of t ◊

"Milton Safenowitz Fellowship awarded to University of Toronto researcher"
7.  Mutant Protein May Act Outside Cells in ALS Findings

Canadian scientist Jean-Pierre Julien presented new evidence that a mutant protein associated with some inherited forms of ALS may be secreted outside cells and act in a toxic manner, providing insigh ◊

"Mutant Protein May Act Outside Cells in ALS Findings"
8.  Jason Wilson receives Brain Star award

In recognition of his article entitled “Quantitative measurement of neurodegeneration in an ALS-PDC model using MR microscopy”, University of British Columbia PhD fellow Jason Wilson has been awarded ◊

"Jason Wilson receives Brain Star award"
9.  New Research Grant for Dr. Jean-Pierre Julien

Dr. Jean-Pierre Julien, an ALS Society of Canada board member and a prominent ALS researcher at Laval University Research Centre in Quebec has been awarded a research grant from the the ALS Associatio ◊

"New Research Grant for Dr. Jean-Pierre Julien "
10.  Novartis Drug Does Not Slow ALS Progression

Novartis has been conducting a Phase 2 trial with its drug TCH 346 and has advised that the drug has shown no impact on the rate of progression or survival of ALS. For more information click on www.a ◊

"Novartis Drug Does Not Slow ALS Progression"
11.  Ottawa Regional ALS Conference

The ALS Society of Ontario, Champlain Region and the Rehabilitation Centre, Ottawa are pleased to announce their first one-day interactive conference for people affected by ALS: families, friends, vol ◊

"Ottawa Regional ALS Conference"
12.  Oxidative Stress Not the Whole Story

Dr.Heather Durham's research, funded in part by the ALS Society is searching for new ways to augment defensive mechanisms to assist cells in defending themselves against multiple disease-causing stre ◊

"Oxidative Stress Not the Whole Story"
13.  Catch a Wave

New technology is allowing locked-in patients to communicate — using their brainwaves. Relax. Take a moment. Keep your eyes open and focus on a single spot. ◊

"Catch a Wave "
14.  ALS May Hit Gulf War Vets Twice as Often

Veterans who were deployed to the Gulf War may be developing a higher rate of ALS. New research into the occurrence of ALS in American veterans deployed to the Persian Gulf during the 1991 Gulf War re ◊

"ALS May Hit Gulf War Vets Twice as Often"
15.  HAART Offers New Insights

When ALS clinician and researcher Dr. John Turnbull gave his patient, Elizabeth Grandbois, HAART, she showed significant improvement. Now a clinical trial is underway to determine if and how the drug ◊

"HAART Offers New Insights"
16.  A Fundamental Discovery About the Basis for ALS

Scientists have made a fundamental discovery that could reveal a common underlying mechanism of ALS and other forms of Motor Neuron Disease (MND). The findings, from researchers in the United Kingdom ◊

"A Fundamental Discovery About the Basis for ALS "
17.  Scientists Announce Two New Genetic Sites Linked to Familial ALS

Genetic sites on chromosomes 16 and 20 appear to have links to ALS. Genetic screening of four families with familial ALS (fALS) revealed a common suspect region on chromosome 16, and a link to chromos ◊

"Scientists Announce Two New Genetic Sites Linked to Familial ALS "
18.  Gene Therapy Prolongs Mouse Life

A new scientific breakthrough offers hope for an effective therapy for ALS. The gene for a nerve-nourishing protein was packaged in a viral vector and successfully delivered to the nervous systems of ◊

"Gene Therapy Prolongs Mouse Life"
19.  Stem Cell Therapy

New Hopes and Realities. Stems cells are an important part of the future of ALS research, say scientists. But both their advantages and challenges must be kept in perspective. ◊

"Stem Cell Therapy"
20.  New Horizons in Canada and Beyond ...

Good Neighbours,Bad Neighbours: Non-neuronal play an active role in ALS. A new study led by researchers at University of California demonstrates for the first time in mouse models that the cells surro ◊

"New Horizons in Canada and Beyond ... "
21.  Understanding SOD-1

Several mutations in SOD-1 have been identified in patients. But how do these mutations result in toxic proteins, and what can knowing the mutation-type tell us about the behaviour of disease? Dr. Eli ◊

"Understanding SOD-1"
22.  A Fresh Perspective on ALS

Peripherin is a key protein found in the neurofilament aggregates that clog motor neurons in ALS. By searching for toxic mutations in peripherin, Dr. Janice Robertson hopes to discover the mechanisms ◊

"A Fresh Perspective on ALS "
23.  What Tissue Repair Reveals About ALS

When healthy tissues become damaged, they have surprising powers of regeneration. But do ALS-affected tissues always behave in the same way? Dr. Tessa Gordon says that when they don’t, it can provide ◊

"What Tissue Repair Reveals About ALS "
24.  New Frontiers in ALS Research

Dr. Michael Strong is a leading ALS clinician and researcher. With help from the NRP, he is discovering the role of neurofilament aggregates in ALS pathways. ◊

"New Frontiers in ALS Research "
25.  Fishing for Therapies

Dr. Greg Ross is investigating the molecular pathways that lead to cell death in order to discover drugs that can block those pathways—and keep motor neurons alive. ◊

"Fishing for Therapies "
26.  ALS Research, With a Little Help from Some Mice

Animal models help researchers investigate the causes of ALS. By mutating his way through the entire mouse genome, Dr. John Roder is developing new animal models for ALS research and contributing to n ◊

"ALS Research, With a Little Help from Some Mice "
27.  Calcineurin's Orchestral Manoeuvres in Muscle

Dr. Robin Michel was the first to demonstrate calcineurin’s crucial role in the growth of adult muscle. With the hope that his research in muscle signalling may lead to new therapies. Already, Mich ◊

"Calcineurin's Orchestral Manoeuvres in Muscle "
28.  Pathways to Cell Survival

The regulatory pathways that lead to the death of motor neurons in ALS could be the result of an imbalance of key enzymes. Dr. Charles Krieger is investigating how these enzymes contribute to cell dea ◊

"Pathways to Cell Survival "
29.  Food Therapy?

Could a phytochemical found naturally in food help delay the onset of ALS? Dr. Bernhard Juurlink is using ALS mouse models to find out. ◊

"Food Therapy?"
30.  ALS From All Angles

Why do motor neurons die in ALS? Dr. Heather Durham and her team seek to understand the unique vulnerabilities of motor neurons in order to help them live. ◊

"ALS From All Angles"