ALS Disrupt provides a unique experience within the global ALS ecosystem that brings key opinion leaders together to have candid conversations on important and timely topics in front of an audience, rather than in individual conversations, with the goal of collectively tackling complex issues and exploring novel solutions. ALS Disrupt will bring the important, serious discussions the field needs into a fun, collegial atmosphere, with the goal of accelerating impact toward a world free of ALS.
Dates: April 25 – 26, 2026
Location: Sheraton Toronto Airport Hotel & Conference Centre, Etobicoke, ON
Registration for ALS Disrupt 2026 is now open!
Registration is available on a first-come, first-served basis. We strongly encourage you to book early to secure your spot at this unique event that brings together global leaders in ALS research and care.
Register now.
Registration deadline: Friday, March 27, 2026
Registration Fee:
Early Bird (until Monday, February 23, 2026): CAD $300
Regular: CAD $400
Industry: CAD $1,000
Your Registration Includes:
Full access to ALS Disrupt (Day 1 & Day 2), featuring:
- All sessions and scientific highlights
- Networking opportunities with leading experts and key opinion leaders
- Meals and complimentary refreshments throughout the event
Travel and accommodation are not included in the registration fee and must be booked independently. Please see details below.
Due to the scientific nature of the discussions and content, this event is designed specifically for researchers, clinicians, and professionals working in the ALS field. It is not intended for a lay audience.
We recognize the importance of patient representation in shaping the future of ALS research and care. A small number of people affected by ALS will be present by invitation only, ensuring their voices are heard.
Day 1
Saturday, April 25, 2026
5:00 p.m. – 11:00 p.m. ET
ALS Disrupt begins on April 25 with an exciting evening of scientific exchange and networking. The program features a plenary lecture, rapid-fire presentations from Canadians researchers, and an introduction to ALS Disrupt. The night includes a buffet dinner and reception.
Day 2
Sunday, April 26, 2026
8:00 a.m. – 3:30 p.m. ET
The following day, the program will feature four dynamic sessions focused on timely, critical topics in ALS research. Throughout the event, there will also be networking opportunities to connect with global leaders, researchers, and advocates.
Sessions at ALS Disrupt are designed to move beyond traditional presentations and foster open, candid dialogue among experts.
Each discussion begins with brief opening perspectives from panelists providing their insights on the topic and the current state of the field. After these initial remarks, the session transitions into a moderated, interactive discussion and debate, encouraging diverse viewpoints, real-time problem-solving, and collaborative exploration of novel ideas. This format ensures that conversations are dynamic, inclusive, and focused on driving meaningful progress in ALS research and care.
Session #1: What is the minimum preclinical evidence to prioritise a drug for therapeutic evaluation?
Session #2: TDP-43: pathological cornerstone or tombstone?
Session #3: On what should we base decisions about which drugs to move from Phase 2 to 3?
Session #4: What areas of dogma in ALS research should we be discussing more constructively?
The detailed agenda will be posted as soon as it becomes available.
Travel and accommodation are not included in the registration fee and must be booked independently.
ALS Disrupt attendees can book accommodations under ALS Canada’s room block at the Sheraton Toronto Airport Hotel & Conference Centre (801 Dixon Rd, Etobicoke, ON M9W 5P1) until April 02, 2026.
Book your group rate for ALS Disrupt
- Room Rate: CAD $205 per night
- Rate Start Date: Friday, April 24, 2026
- Rate End Date: Sunday, April 26, 2026
- Deadline to book: Thursday, April 02, 2026
Rooms are available on a first-come, first-served basis, and availability is limited. We strongly encourage you to book early to secure your spot.
At this time, accessible rooms at the Sheraton are no longer available. If you require an accessible room, please take this into consideration when booking your accommodations.
Additional Nearby Hotels
If the room block is full, here are several hotels located within walking distance of the conference venue. ALS Canada does not have rates at these locations.
Toronto Airport Marriott Hotel – 901 Dixon Rd (approx. 600 m from the Sheraton)
Residence Inn by Marriott Toronto Airport – 17 Reading Ct, Etobicoke (approx. 650 m from the Sheraton)
Sandman Signature Toronto Airport Hotel – 55 Reading Court (approx. 750 m from the Sheraton)
Embassy Suites by Hilton Toronto Airport – 262 Carlingview Dr (approx. 800 m from the Sheraton)
Courtyard by Marriott Toronto Airport – 231 Carlingview Dr (approx. 850 m from the Sheraton)
The Sheraton Toronto Airport Hotel & Conference Centre offers a complimentary 24-hour airport shuttle to and from Toronto Pearson International Airport (YYZ). There is no airport shuttle from Billy Bishop Toronto City Airport (YTZ).
Hotel Pickup
Pickups at approximately 00:25 and 00:55 of every hour between 5:44 am until 11:25 pm.
Airport Pickup
- Terminal 1: Post F3
- Pickups at approximately 00:20 and 00:50 of every hour.
- Terminal 3: Post 41
- Pickups at approximately 00:15 and 00:45 of every hour.
The shuttle has the Sheraton logo as well as the Crowne Plaza logo on the side and front of the bus.
Please call the hotel at 416-675-6100 if the shuttle is more than 10 minutes late past the pickup time.
Self-parking will be available on-site at the hotel for all ALS Disrupt attendees. Upon arrival, please check in at the front desk to register your vehicle and for payment.
Our Sponsors
ALS Disrupt was made possible thanks to the generous support from:
