ALS Disrupt provides a unique experience within the global ALS ecosystem that brings key opinion leaders together to have candid conversations on important and timely topics in front of an audience, rather than in individual conversations, with the goal of collectively tackling complex issues and exploring novel solutions. ALS Disrupt will bring the important, serious discussions the field needs into a fun, collegial atmosphere, with the goal of accelerating impact toward a world free of ALS.
Dates: April 28–30, 2027
Location: Sheraton Centre Toronto Hotel, Downtown Toronto, 123 Queen St W, Toronto, ON M5H 2M9
Explore the provisional programme below. You can also read recaps from previous meetings here.
Registration for ALS Disrupt 2027
Registration is limited and available on a first-come, first-served basis. The first 100 spots are now open. We cannot guarantee how many additional spots will be openly available after these are gone. We encourage you to register early to secure your place.
Registration fees:
- Academic/Non-Profit/Community registration: CAD $700
- Industry registration: CAD $1,400
The content and discussions at ALS Disrupt are designed for scientific, clinical and other expert discussions on key topics in the field. Everyone is welcome, but the event is not designed for a lay audience.
Programme details and session titles are provisional and subject to change.
Day 1
Wednesday, April 28, 2027
ALS Disrupt begins with the inaugural ALS Disrupt Lecture featuring Jeffrey Rothstein, followed by a welcome, dinner, drinks and scientifically theatrical participant introductions.
Day 2
Thursday, April 29, 2027
Four moderated sessions will explore important questions in ALS research, followed by the Spirited Solutions Cocktail Hour, a collective workshop to help identify a path forward.
Session #1: What would it take to believe an ALS treatment works?
Session #2: What is the best therapeutic approach to C9orf72 in 2027?
Session #3: The good and the bad of using iPSCs and induced neurons/glia to inform ALS biology and treatment
Session #4: How do we balance rigorous science with business considerations in ALS drug development?
Day 3
Friday, April 30, 2027
The final day features The Showdown 2027 trivia contest (resurrected from the ALS Canada Research Forum – subject to change), Speakers Corner (new! – see provisional programme), Disrupt Q&A (new! – see provisional programme) and a fifth panel discussion, before a vote and event wrap-up.
Session #5: Moonshots or building blocks? Should we prioritize our efforts on finding transformative therapies or a combination of modest effects?
Moderated by Dr. Michael Benatar (USA) and Dr. Martin Turner (UK).
Session 1
Session 2
Session 3
Session 4
Session 5
The conference hotel, Sheraton Centre Toronto Hotel at 123 Queen Street West, Toronto, has a limited room block available for ALS Advance attendees at a rate of CAD $337 per night, plus applicable taxes and fees. Registrants may either use the booking button below or call toll-free at 1-888-627-7175 and state that you are with the ALS Advance 2027 block to make your reservation. The rate is available for the nights of Wed, April 28 and Thurs, April 29.
Accessibility: Please contact the Research Team at alsadvance@als.ca should you need an accessible room and any accommodation needs.
